Causes of RLS

In most cases, the cause of RLS is unknown. A family history of the condition is seen in approximately 50% of such cases, suggesting a genetic form of the disorder. People with familial RLS tend to be younger when symptoms start and have a slower progression of the condition.

In other cases, RLS appears to be related to the following factors or conditions, although researchers do not yet know if these factors actually cause RLS.

• People with low iron levels or anemia may be prone to developing RLS. Once iron levels or anemia is corrected, patients may see a reduction in symptoms.
• Chronic diseases such as kidney failure, diabetes, Parkinson's disease, and peripheral neuropathy are associated with RLS. Treating the underlying condition often provides relief from RLS symptoms.
• Some pregnant women experience RLS, especially in their last trimester. For most of these women, symptoms usually disappear within 4 weeks after delivery.
• Certain medications, such as anti-nausea drugs, anti-psychotic drugs, and some cold and allergy medications, may aggravate symptoms. Patients who experience RLS symptoms should talk with their physicians about the possibility of changing medications.⁽¹⁾